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Cardiomyopathy of Transthyretin-Mediated Amyloidosis
Medications for Amyloid Cardiomyopathy
Other titles: Cardiomyopathy of Transthyretin-Mediated Amyloidosis
Amyloid cardiomyopathy (cardiac amyloidosis) is really a heart disease that is due to an abnormal sort of protein (amyloid) gathering over the center cells. This eventually reduces the capability for the center to work either having problems filling or pumping. The amyloid deposits can also influence the electric conduction in the center that can lead to arrhythmias (abnormal heart beats ) and heart problems.
You`ll find two proteins that create cardiac amyloidosis. 1 protein is called amyloid light chain (AL) and one different protein is amyloid transthyretin (ATTR). Sub types of all ATTR comprise wildtype ATTR (ATTRwt), which has ordinary amyloid transthyretin protein that is slowly deposited over the center within several years and causes era related amyloidosis. In mutant ATTR (ATTRm) amyloidosis subtype there`s actually a mutation in the transthyretin gene that causes amyloid residue to accumulate at a faster rate.
Diagnosis of the sub type of all amyloidosis is essential to know the disease form, progression, treatment and prognosis.
There are just two aspects of managing cardiomyopathy. The very first purpose is treating cardiac signs of arrhythmias, heart failure and complications that are pericardial. The other aspect of treatment is to decrease amyloid deposition.
For AL amyloidosis is employed to slow the progression of accumulation. In ATTR amyloidosis, with regards to the specific sub type, selective stabilizers of TTR may be employed to decrease the process of amyloid formation.
Drugs Used to Heal Amyloid Cardiomyopathy
The following listing of medications have been in some way associated with, or utilized in the treatment of this illness.
| Medication title | Rx / OTC | Pregnancy | CSA | Alcohol | Reviews | Rating | Popularity |
|---|---|---|---|---|---|---|---|
| tafamidis | Rx | N | Two reviews | 6.0 | |||
Generic title: tafamidis systemic Brand titles: Vyndamax, Vyndaqel Medication class: transthyretin stabilizers For consumers: interactions, For specialists: A-Z Drug Truth, AHFS DI Monograph | |||||||
| Vyndamax | Rx | N | Insert inspection | 0.0 | |||
Generic title: tafamidis systemic Medication class: transthyretin stabilizers For consumers: interactions, side effects | |||||||
| Vyndaqel | Rx | N | Insert inspection | 0.0 | |||
Generic title: tafamidis systemic Medication class: transthyretin stabilizers For consumers: dosage, interactions, side effects For professionals: Prescribing Information | |||||||
Legend
| Rx | Prescription Only |
|---|---|
| OTC | Over the Counter |
| Rx/OTC | Prescription or Over The Counter |
| Away Tag | This drug may not be approved by the FDA for the treatment of this illness. |
| Pregnancy Category | |
|---|---|
| A | sufficient and well-controlled studies have failed to present a risk to the fetus within the first trimester of pregnancy (also there is no evidence of risk in later trimesters). |
| B | Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no sufficient and well-controlled studies in elderly women. |
| C | Animal reproduction studies have shown a negative effect on the fetus and there are no sufficient and well-controlled studies in humans, but possible benefits may warrant used in pregnant women despite potential risks. |
| D | There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but possible benefits may warrant used in pregnant women despite potential risks. |
| X | Studies in animals or humans have demonstrated fetal abnormalities or there`s positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and also the risks involved with used in elderly women clearly outweigh potential benefits. |
| N | FDA have not classified the medication. |
| Controlled Substances Act (CSA) Program | |
|---|---|
| N | Is not at the mercy of the Controlled Substances Act. |
| 1 | features a higher possibility of misuse. Has no currently accepted medical use in treatment in the United States. There`s a lack of accepted safety for use under medical supervision. |
| Two | features a higher possibility of misuse. Includes a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Psychotherapy can lead to severe psychological or physical dependency. |
| 3 | includes a potential for abuse less than people in schedules 1 and 2. Includes a currently accepted medical use in treatment in the United States. Psychotherapy can lead to physical dependence or high psychological dependence. |
| 4 | features a low potential for abuse relative to people in schedule 3. It`s a currently accepted medical use in treatment in the United States. Psychotherapy can lead to limited physical dependence or psychological dependence. |
| 5 | features a low potential for abuse relative to people in schedule 4. Includes a currently accepted medical use in treatment in the United States. Psychotherapy can lead to limited physical dependence or psychological dependence. |
| Alcohol | |
|---|---|
| X | Interacts with Alcohol. |
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Always consult your healthcare provider to make sure the information displayed on this page relates to your circumstances.
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